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Open Research Studies

The following research studies are open and available for interested patients who wish to participate. Please note that these research projects listed below are not the only available studies relating to spinal deformity, nor are these studies necessarily endorsed by the Scoliosis Research Society. For further information, please email or call the contact person named in the study description.

Minimize Implants Maximize Outcomes (MIMO) Clinical Trial

Minimize Implants Maximize Outcomes (MIMO) Clinical Trial

The Minimize Implants Maximize Outcomes (MIMO) Clinical Trial is conducting a prospective randomized controlled study to determine whether using fewer screws has equivalent results to using more screws for fusion surgery in adolescent idiopathic scoliosis. The hypothesis is that no significant differences exist in percent major Cobb angle correction between high- and low-implant density cohorts for Lenke 1A curve types. Consecutive qualifying patients will be enrolled and randomized to spinal instrumentation with a low- or high-density screw pattern. Both treatment arms are considered standard of care. Patients will follow-up at 3-months, 1-year, and 2-years. Although the study is primarily powered to detect change in percent correction of the major coronal curve, preliminary data will be gathered on axial and sagittal plane correction as well as complications, surgical factors, and patient-reported outcomes. Approximately 130 patients have been enrolled at 13 US and Canadian sites. Target enrollment is 200 patients. The study is funded by the Orthopaedic Research and Education Foundation.

To learn more about the MIMO Clinical Trial, click here.