Scoliosis Research Society (SRS)
Scoliosis Research Society (SRS)
An International Organization Dedicated to the Education, Research and Treatment of Spinal Deformity
Our Mission is to Foster Optimal Care for All Patients with Spinal Deformities
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Outcomes

Principal Investigator Title of Grant Amount
of Grant
Year
Aronsson, David D. The contribution of Asymmetric Growth and Vertebral Remodeling to Apical Wedging $41,829 2008
  Presentations:
  1. The Contribution of Asymmetric Growth and Remodeling to Apical Wedging: A Preliminary Report University of Vermont Research Day 2009
     
  2. The Contribution of Asymmetric Growth and Remodeling to Apical Wedging Quebec Scoliosis Society, 2009
     
  3. The Contribution of Asymmetric Growth and Remodeling to Apical Wedging in Scoliosis International Research Society of Spinal Deformities, 2010
  4. The Role of Remodeling and Asymmetric Growth in Vertebral Wedging Scoliosis Research Society, 2010; Combined Meeting of the Korean Paediatric Orthopaedic Society and the International Federation of Paediatric Orthopaedic Societies, 2010; Quebec Scoliosis Society, 2010
Publications:
  1. Aronsson, DD, Stokes, IA, McBride, CA. The Role of Remodeling and Asymmetric Growth in Vertebral Wedging. Studies in Health Technology and Informatics. 158:11-15, 2010.
  2. Aronsson, DD, Stokes, IA, McBride, CA. The Role of Remodeling and Asymmetric Growth in Vertebral Wedging. In Research into Spinal Deformities 7. Eds. Aubin C-E, Stokes IAF, Labelle H, Moreau A. Amsterdam, Netherlands, IOS Press, 2010, pp 11-15.
Briggs, Andrew Measurement of vertebral subregional bone mineral density using lateral-projection DXA: Establishing concurrent and predictive validity $10,000 2008
  Publications:

AM Briggs, E Perilli, IH Parkinson, TV Wrigley, NL Fazzalari, S Kantor, JD Wark. Novel assessment of subregional bone mineral density using DXA and pQCT, and subregional micro-architecture using micro-CT in whole vertebrae: Applications, methods, and correspondence between technologies.
Journal of Clinical Densitometry: Assessment of Skeletal Health. 13:2, 161-174, 2010.
 

Wise, Carol Identification of Genetic Susceptibility in Idiopathic Scoliosis $89,000 2006 & 2008
 

Presentations:

Genetics of idiopathic scoliosis: Insights into a common and complex disease of childhood, International Cotrel Symposium, 2008

Is genetic research of any use to the scoliosis surgeon? British Scoliosis Society, 2009

Genetics of idiopathic scoliosis, insights into a common and complex disease of childhood Musculoskeletal Genetics Symposium, Washington University St. Louis School of Medicine, 2009

Genome-wide study reveals chromosome 3 variants associated with idiopathic scoliosis NICHD Structural Birth Defects Meeting, 2009

Genome-wide association studies of idiopathic scoliosis Brandon Carrell symposium, Texas Scottish Rite Hospital for Children, 2010

Genome-wide Study Reveals Region of Chromosome 3 Associated with Idiopathic Scoliosis Pediatric Orthopaedic Society of North America, 2010

Genome-wide Study Reveals Genetic Loci Associated with Idiopathic Scoliosis Scoliosis Research Society, 2010

Poster Presentations:

Genome-wide association studies of adolescent idiopathic scoliosis suggest genes encoding axon guidance molecules as candidates for disease susceptibility American Society of Human Genetics, 2010

Genome-wide searches for idiopathic scoliosis susceptibility loci Genomics of Common Diseases, 2010

Publications:

A family-based likelihood ratio test for general pedigree structures that allows for genotyping error and missing data. Y Yang, CA Wise, D Gordon, SJ Finch. Human Heredity 66(2), 99-110, 2008. PMID: 18382089

Evaluation of GPR50, hMel-1B, and ROR-a Melatonin-related Receptors and the Etiology of Adolescent Idiopathic Scoliosis. William Shyy, Kai Wang, Christina A. Gurnett, Matthew B. Dobbs, Nancy H. Miller, Carol Wise, Val C. Sheffield, Jose A. Morcuende. J Pediatr Orthop 30(6), 539-43, 2010. PMID: 20733416.

Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes. Swarkar Sharma, Xiaochong Gao, Douglas Londono, Shonn E. Devroy, Kristen N. Mauldin, Jessica T. Frankel, January M. Brandon, Dongping Zhang, Quan-Zhen Li, Matthew B. Dobbs, Christina A. Gurnett, Struan F.A. Grant, Hakon Hakonarson, John P. Dormans, John A. Herring, Derek Gordon, and Carol A. Wise, Human Mol Genet in press, PMID: 21216876. Current Understanding of Genetic Factors in Idiopathic Scoliosis, S Swarkar, C Wise, In: Kenro and Dunwoodie (ed) The Genetics and Development of Scoliosis, Springer, 167-190, 2009.

Genetics, S Swarkar, C Wise, In: Song (ed) Pediatric Orthopaedics, Orthopaedic Knowledge Update, American Association of Orthopaedic Surgeons, in press.
 

Labelle, Hubert Towards a 3D Classification of Adolescent Idiopathic Scoliosis $49,600 2008
 

Presentations:

3D sub-classification of Lenke 1 curves
Scoliosis Research Society, 2008

The standard lateral radiograph radiograph does not represent reality at the thoracic apex in AIS: a 3D analysis confirms lordosis
Scoliosis Research Society, 2008

Proposal for a reference axis as a basis for 3D classification of idiopathic scoliosis
Scoliosis Research Society, 2008

Publications:

Sangole A, Aubin CEA, Stokes IAF, Lenke L, Jackson R, Newton P, Labelle H. Three-dimensional Classification of Thoracic Scoliotic Curves, Spine, Volume 34, Number 1, pp 91–99, 2009.

Duong L, Mac-Thiong JM, Cheriet F, Labelle, H. Three-Dimensional Sub-classification of Lenke Type 1 Scoliotic Curves, J Spinal Disord Tech _ Volume 22, Number 2, April 2009.

Duong L; Cheriet F, Labelle H, Cheung K, Abel M, Newton P, McCall R, Lenke L, Stokes IAF. Intra and Inter-Observer Variability in the Identification of the Lumbar Modifier in AIS, J Spinal Disord Tech _ Volume 22, Number 6, August 2009.

Stokes IAF; Sangole AP; Aubin, CE. Classification of scoliosis deformity 3D spinal shape by cluster analysis, SPINE Volume 34, Number 6, pp 584–590, ©2009.

Hayashi K, Upasani VV, Pawelek JB, Aubin CE, Labelle H, Lenke LG, Jackson R, Newton PO. Three-Dimensional Analysis of Thoracic Apical Sagittal Alignment in Adolescent Idiopathic Scoliosis, Spine (2009) 34(8):792–797.

Sangole A, Aubin CE, Labelle H, Lenke L, Jackson R, Newton P, Stokes IAF. The Central Hip Vertical Axis (CHVA): A Reference Axis for the SRS 3D Classification of Idiopathic Scoliosis, In Press, Spine • Volume 35 • Number 12 • 2010.

Li, Xudong Nucleus Pulposus Regeneration with Genetically Engineered Fat-derived Stem Cells $100,000 2007
 

Presentations:

Nucleus Pulpous Explant Culture Model
Orthopaedic Research Society, 2009

Ectopic bone formation in the endplate of apoE deficient miceM
Orthopaedic Research Society, 2010

Publications:

Feng G, Yang X, Shang H, Marks IW, Shen FH, Katz A, Arlet V, Laurencin CT, Li X. Multipotential differentiation of human anulus fibrosus cells: an in vitro study. J Bone Joint Surg Am. 2010 Mar;92(3):675-85.

Xinlin Yang, Xudong Li. Nucleus pulposus tissue engineering: state of the art. European Spine Journal.

Schwab, Frank Adult Deformity: Development of an Effective Treatment Algorithm Based upon Outcomes Analysis $94,000 2007
 

Presentations:

Predicting Surgical Outcome by Change in Critical Parameters of Thoracolumbar Lumbar Spinal Deformity in Adults
Scoliosis Research Society, 2008

A consensus algorithm for treating adult thoracic major spinal deformity is helpful in guiding surgical treatment
IMAST, 2009

Does a consensus algorithm for treating adult thoracolumbar and lumbar major spinal deformity help guide optimal treatment?
Scoliosis Research Society, 2009

Breden, Felix The guppy 'curveback' mutant as a model for spinal deformity $10,000 2005
 

Presentations:

The guppy as a model for heritable spinal curvature in humans
Aquatic Models of Human Disease Conference, 2005

The guppy as a model for human idiopathic curvature
Genomics and the Life Aquatic Conference, 2006

Poster Presentation:

The guppy curveback syndrome as a model for human idiopathic spinal curvature
Environmental Mutagen Society, 2006

Patel, Robin Biofilms and Spinal Instrumentation $99,850 2005
 

Presentations:

A Biofilm Approach to Detect Bacteria on Explanted Spinal Implants: Preliminary Data
Scoliosis Research Society, 2007

Cheung, Kenneth MC Surface modification of Nitinol by Plama Immersion Ion Implantation $100,000 2005
 

Presentations:

Novel Plasma-Implanted 'Smart' Metallic Materials for Orthopedic Implants
International Conference on Metallurgical Coatings and Thin Films. San Diego, California, USA

Novel Plasma Modified Shape Memory Materials For Orthopaedic Implantation
53rd Annual Meeting of Orthopaedic Research Society. San Diego, USA

New Plasma Surface Treated Memory Alloys: Towards a New Generation of "Smart" Orthopaedic Materials
Materials Science & Technology 2006 Conference & Exposition. Cincinnati, Ohio, USA

Novel plasma-implanted shape memory alloys in orthopedics
15th International Conference on Ion Beam Modification of Materials. Taormina, Sicily, Italy

Suppression of nickel release in nickel-titanium alloys by plasma immersion ion implantation surface treatment: towards a new generation of "smart" orthopaedic implants
33rd IEEE International Conference on Plasma Science. Traverse City, Michigan, USA

Publications:

KWK Yeung, YL Chan, KO Lam, XM Liu, SL Wu, XY Liu, CY Chung, WW Lu, D Chan, KDK Luk, PK Chu, KMC Cheung. New Plasma Surface Treated Memory Alloys: Towards A New Generation Of "Smart" Orthopaedic Materials. Materials Science and Engineering C: Biomimetic and Supramolecular Systems 2007.

Surface mechanical properties, chemicals composition and osteoblast viability of nitrogen plasma-implanted nickel titanium alloy, medical grade stainless steel and Ti-6A1-4V alloy. Journal of Biomedical Materials Research Part A, 2006.

Additional Funding:

Innovation and Technology Fund – Guandong and Hong Kong Technology Cooperation Funding Scheme: Project Title: Optimization and Commercialization of Novel Metallic Materials for Orthopaedic Use – US$1.2 million (2006-2008)

Nachemson, Alf A continuation of the "SRS study for brace treatment of adolescent idiopathic scoliosis - follow-up of the Swedish patients at least 10 yrs after maturity $47,020 2005
 

Presentations:

Curve progression at least ten years after maturity in patients with moderate adolescent idiopathic scoliosis – a prospective comparison of observation or brace treatment
Scoliosis Research Society, 2006

Giampietro, Phillip Mutation Analysis in Human Congenital Scoliosis and Vertebral Malformations $77.077 2004
 

Presentations:

A Nonsynonymous WNT3A mutation in a patient with congenital scoliosis.
Scoliosis Research Society, 2006.

DLL3 as a candidate gene for human vertebral malformations.
Wisconsin Symposium on Human Biology, 2006

Publications:

DLL3 as a candidate gene for vertebral malformations. Am J Med Genet A 2006;140A:2447-2453.

Evaluation of SLC35A3 as a candidate gene for human vertebral malformations. Am J Med Genet A 2006;140:1346-1348.

An analysis of PAX1 in the development of vertebral malformations. Clin Genet. 2005 Nov;68(5):448-53

Cheng, Jack Are VDR, Era and PTHR1 Genes Associated With The Occurrence As Well As Abnormality In Bone Growth And Sexual Maturation In Adolescent Idiopathic Scoliosis $70,800 2003
 

Presentations:
  1. JCY Cheng, CSK Cheung, KM Lee, X Guo, L Qin, HY Yeung, CW Chan, WTK Lee, NL Tang. Association between Estrogen Receptor (ESR) Gene Polymorphism and Growth Disturbance in Adolescent Idiopathic Scoliosis (AIS). In: Spinal Deformities Research. International Research Society for Spinal Deformities Symposium 2004. Edi: Sawatzky BJ. P. 80-82.
     
  2. Cheung CSK, Lee WTK, Cheng JCY, Chan CW, Lee KM, Leung C, Guo X, Qin L. Association between estrogen receptor (esr) gene polymorphism and growth disturbance in adolescent idiopathic scoliosis (AIS). 23rd Annual Congress of the Hong Kong Orthopaedic Association. 8-9 Nov, 2003, Hong Kong. Hong Kong J Ortho Surg 2003, 7 (Suppl), p. S37
     
  3. Cheng JCY, Cheung CSK, Lee KM, Leung C, Guo X, Qin L, Chan CW, Yeung B, Lee WTK. Peripubertal Growth Disturbance in Adolescent Idiopathic Scoliosis (AIS) is associated with Estrogen Receptor (ESR) Gene Polymorphism (PvuII). Abstracts of the 38th Annual Meeting, Scoliosis Research Society, Quebec, Canada, Sept 10-13, 2003. P. 143.
Wise, Carol Localization & Analysis of Candidate Genes of Idiopathic Scoliosis $36,666.50 2002
  Publications:

"SNTG1", the gene encoding gamma1-syntrophin: a candidate gene for idiopathic scoliosis. Bashiardes S., Veile R., Allen M, Wise CA, Dobbs M, Szappanos L, Herring JA, Bowcock AM, Lovett M. Hum Genet 115, 81-89 (2004).

Published Abstracts:

Wise CA, Herring JA, Gao XC, Cain NM, Swaney SL, Bashiardes S, Veile R, Bowcock AM, Lovett M. Mapping susceptibility loci for idiopathic scoliosis, American Society of Human Genetics annual meeting, Oct. 2004, Toronto, Canada (accepted for poster presentation).

Bashiardes S, Veile R, Wise CA, Szappanos, Lovett M. A candidate gene for idiopathic scoliosis. American Society of Human Genetics annual meeting, Oct. 2003, Los Angeles, CA (poster presentation).

Presentations

Wise CA. Molecular genetics of idiopathic scoliosis. Presentation to Medtronic Foundation, Dallas, TX, March 2001.
Cheng, Jack Relationship between Postural Balance, Somatosensory Evoked Potential and the Progression of Scoliotic Deformity in the AIS $70,800 2001
 

Presentations:

1. Guo X, Chaw WW, Cheung SK, Tsang WWN, Hui-Chan WY, Cheng JCY. Postural Balance Control in Adolescents with Idiopathic Scoliosis (AIS) and Abnormal Somatosensory Function. In: Spinal Deformities Research. International Research Society for Spinal Deformities Symposium 2004. Edi: Sawatzky BJ. P. 368-71.

2. Chau WW, Guo X, Fu LLK, Ng BKW, Lam TP, Chan YL, Cheng JCY. Abnormal Somatosensory Evoked Potential (SSEP) in Adolescent with Idiopathic Scoliosis - The Site of Abnormality. International Research Society for Spinal Deformities Symposium 2004. Vancouver, Canada, June 10-12, 2004 (Abstract P.279-281)

3. Cheng JCY, Lao MLK, Chow DHK, Guo X. Abnormal Postural Balance and Gait in Adolescent Idiopathic Scoliosis - Correlation with Somatosensory Cortical Evoked Potentials. 2002 Combined Orthopaedic Meeting. Singapore, October 12-16, 2002 (Abstract, p.233).

4. Guo X, Cheung SK, Tsang WL, Hui-Chan WY, Cheng JCY. Postural Balance Control in Adolescents with Idiopathic Scoliosis (AIS) and Disturbed Somatosensory Function. Progress report 2002, 2003 Paris Fondation Cortrel Scientic meeting.

5. Guo X, Cheung SK, Tsang WL, Hui-Chan WY, Cheng JCY. Postural Balance Control in Adolescents with Idiopathic Scoliosis (AIS) and Disturbed Somatosensory Function. International Research Society for Spinal Deformities Symposium 2004. Vancouver, Canada, June 10-12, 2004 (Abstract P.368-371)
Oheneba Boachie-Adjei, w/ Dr. Raymond Clarke Developmental Basis of the Klippel-Feil Syndrome $60,000 2000
  Publications:

Clarke, PA, Catalan G, Diwan A, Kearsley, JH
Hetrogeneity in Klippel-Feil Syndrome; a new classification
Paediatric Radiology 28 (12): 967-974, 1998.

Clarke, PA, Kearsley JH, Walsh DA
Patterned expression in familial Klippel-Feil Syndrome
Teratology 53 (3): 152-157, 1996.

Clarke, PA, Singh S, Mckenzie H, Kearsley JH, Yip M-Y
Familial Klippel-Feil syndrome and paracentric inversion inv (8) (q22.2q23.3).
American Journal of Human Genetics 57: 1364-1370

Abstracts:
Mutations in the SGM1 gene cause extensive disruption of vertebral segmentation in the KF2 class of Klippel-Feil syndrome.
Cheng, Jack Loss of Synchronous Coupling of Endochrondral and Membranous Ossification in AIS: The Morphological and Biological Evidences $35,400 1999
  Publications:

1. Tang SP, Cheng JCY, Ng BKW, Lam TP. Adolescent Idiopathic Scoliosis (AIS): An overview of the etiology and basic management principles. HK J Paediatr 2003;8:299-306

2. Guo X, Chau WW, Chan YL, Cheng JCY. Relative Anterior Spinal Overgrowth in Adolescent Idiopathic Scoliosis - Result of Disproportional Endochondral-membranou Bone Growth. J Bone Joint Surg 2003;85B:1026-31

3. Cheng JC, Tang SP, Guo X, Chan CW, Qin L. Osteopenia in adolescent idiopathic scoliosis: a histomorphometric study. Spine 2001;26:C1-5.

4. Cheng JCY, Chau WW, Guo X, Chan YL (2004): In response. Spine 29: 105-9

5. EFG discussions on "Relative Anterior Spinal Overgrowth in Adolescent Idiopathic Scoliosis - Result of Disproportional Endochondral-membranou Bone Growth." Round 1-4

6. Cheung SK, Lee TK, Tse YK, Tang SP, Lee KM, Guo X, Qin L, Cheng JCY (2003): Abnormal peri-pubertal anthropometric measurements and growth pattern in adolescent idiopathic scoliosis: a study of 598 patients. Spine 28: 2152-7

7. Cheng JCY, Tang SP, Guo X (2002): Advances in study on etiology of adolescent idiopathic scoliosis (I). Chin J Spine Spinal Cord 12 (2): 139-41

8. Cheng JCY, Tang SP, Guo X (2002): Advances in study on etiology of adolescent idiopathic scoliosis (II). Chin J Spine Spinal Cord 12 (3): 221-3

Presentations:

1. Chau WW, Guo X, Fu LLK, BKW Ng, Lam TP, Chan YL, Cheng JCY. Abnormal Somatosensory Evoked Potential (SSEP) in Adolescent with Idiopathic Scoliosis - The Site of Abnormality. International Research Society of Spinal Deformities Symposium 2004. June 10-12, 2004, Vancouver, Canada. P. 279-81.

2. Cheng JCY, Lee WTK, Chau WW, Cheung SK, Guo X, Chan YL. Abnormal Anthropometric Growth and Relative Spinal Overgrowth in Adolescent Idiopathic Scoliotic (AIS) Patients. In: Spinal Deformities Research. International Research Society for Spinal Deformities Symposium 2004. June 10-12, 2004, Vancouver, Canada. P. 275-78.

3. Jack, CY Cheng, Warren TK Lee, Wan W Chau, Catherine SK Cheung, Xia Quo, Leung Yu Chan. Abnormal Anthropometric and Spinal Growth in Adolescents with Idiopathic Scoliosis. 3rd IFPOS Congress -Intl' Federation of Pediatric Orthopedic Socieities, Salvador, Bahia, Brazil. Sep 3-6, 2004, Poster P128, p. 207.

4. Wan W Chau , Xia Quo, Leung Yu Chan, Jack, CY Cheng. Relative anterior spinal overgrowth in adolescent idiopathic scoliosis - result of disproportionate endochondral-membranous bone growth. 77th Annual Congress of Japanese Orthopaedic Association. May 20-23, 2004, Kobe, Japan. P. 116.

5. Cheng JCY, Heung HY, Tang SP, Guo X, Lee KM, Qin L. Low BMD is Associated with Poor Bone Micro-architecture of Trabecular Bone in Adolescent Idiopathic Scoliosis. Scoliosis Research Society 38th Annual Meeting. Quebec, Canada, September 10-13, 2003 (Electronic poster no.10, p.242)

6. Wan W Chau , Xia Quo, Leung Yu Chan, Jack, CY Cheng. Generalised osteopenia in adolescent idiopathic scoliosis (AIS) - asynchronous endochrondral and membraneous ossification of the spine. 2nd HOMA Awarding Ceremony and 2003 Int'l Osteoporosis Conference, Oct, Beijing, China. Poster 35, p. 125

7. W W Chau , X Quo, L Y Chan, J C Y Cheng. Abnormal differential growth - asynchronous endochrondral and membraneous ossification of the spine in adolescent idiopathic scoliosis? A MRI study. 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR). 3-7 June 2003, Osaka, Japan. Bone 2003; 32 (Suppl): P121W, p. S124.

8. TANG Shen Ping, YEUNG Hiu Yan, LEE Kwong Man, QIN Ling, GUO Xia, CHENG Jack. Chun-yiu A Pilot Study of Immunohistochemical Staining of Biglycan and Decorin in Iliac Crest in Adolescent Idiopathic Scoliosis The 6th National Congress of Pediatric Surgery. Chinese Medical Association, Changsha, China, Nov. 25th-30th, Page 28.

8. J C Y Cheng, X Quo, W W Chau, L Y Chan. Lordoscoliosis in adolescent idiopathic scoliosis - A MRI study of the thoracic vertebrae vs normal controls. 2003 Combined Orthopaedic Meeting of Singapore Orthoaedic Association, ASEAN Orthopaedic Association and Spinal and Paediatric Sections, APOA, P. 242. Singapore, 12-16 Oct, 2002.

9. Cheung SK, Cheng JCY, Guo X, Lee WTK, SWE Ng, WY Hung. The Asynchronous Coupling of Endochondral and Membranous Ossification in Girls with Adolescent Idiopathic Scoliosis (AIS). Program & Abstracts of The 1st International Conference on Bone & Mineral Research. September 15-19 2001, Beijing, China. P.66-7.

10. Cheng JCY, Guo X, Lee WTK, Ng SWE, Cheung SK, Hung WY (2001). Asynchronous Coupling of Endochondral and Membranous Ossification in Adolescent Idiopathic Scoliosis (AIS). P.228, Program & Abstracts of 13th Triennial Congress of Asia Pacific Orthopaedic Association, April 1-6 2001, Adelaide, Australia.

11. JCY Cheng, SP Tang, Guo X, KM Lee, L Qin. An Immunohistochemical study on expression of decorin and biglycan in bone of in bone of osteopenic adolescent idiopathic scoliosis girls. 21st Annual Congress, The Hong Kong Orthopaedic Association, Nov 2001, p. S78.

12. JCY Cheng, X Quo, W W Chau, L Y Chan. Lordoscoliosis in adolescent idiopathic scoliosis - A MRI study of the thoracic vertebrae vs normal controls. Program of the 36th Annual Meeting, Scoliosis Research Society, Cleveland, Ohio, USA, Sep 19-22, 2001. p.69.

13. JCY Cheng, SP Tang, Guo X, KM Lee, L Qin. Osteopenia in adolescent idiopathic scoliosis (AIS): Immunohistochemical study of the location and distribution of biglycan and decorin in bone. Program of the 36th Annual Meeting, Scoliosis Research Society, Cleveland, Ohio, USA, Sep 19-22, 2001.

14. Tang SP, Cheng JCY, Guo X, Lee SKM, Qin L. Osteopenia in Adolescent Idiopathic Scoliosis (AIS): Immnohistochemical Study of the Location and Distribution of Biglycan and Decorin in Bone. 36th Annual Meeting of Scoliosis Research Society. Ohio, USA, September 19-22, 2001 (p.156)

15. JCY Cheng, X Quo, WW Chau, LY Chan. MRI vertebrae Morphometry in Growing Adolescents with early scoliosis. Program of the 35th Annual Meeting, Scoliosis Research Society, Cairns, Australia, Oct 18-21, 2000. p.161.

16. JCY Cheng, X Quo, WW Chau, LY Chan. MRI vertebrae Morphometry in Growing Adolescents with early scoliosis. 20th Annual Congress, The Hong Kong Orthopaedic Association, Nov 2000, p. S73.

17. Asynchrony of Endochondral and Membranous Ossification in Adolescent Patients with Idiopathic Scoliosis. 20th Annual Congress, The Hong Kong Orthopaedic Association, Nov 2000, p. S19.

18. Cheng JCY, Guo X, Ng SWE, Cheung SK, Hung WY. Loss of Synchronous Coupling of Endochondral and Membranous Ossification in Adolescent Idiopathic Scoliosis (AIS) 35th Annual Meeting of Scoliosis Research Society Cairns, Australia, October 18-21, 2000 (Proceedings, p.167).

19. Cheng JC, Tang SP, Yeung HY, Lee KM, Guo X, Qin L. Poor trabecular microarchitecture associated with osteopenia in adolescent idiopathic scoliosis. 23rd Annual Congress, The Hong Kong Orthopaedic Association, Nov 2003, p. S110.

20. Chau WW, Guo X, Chan YL, Cheng JCY. Correlations between vertebral height and anthropometric measurements in adolescents with idiopathic scoliosis versus normal subjects. 22nd Annual Congress, The Hong Kong Orthopaedic Association, Nov 2002, p. S69.

21. Cheng JC, Tang SP, Yeung HY, Lee KM, Guo X, Qin L. Change of Trabecular bone micro-architecture of adolescent idiopathic scoliosis with different curve severity . 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR). 3-7 June 2003, Osaka, Japan. Bone 2003; 32 (Suppl).

22. Cheng JC, Tang SP, Yeung HY, Lee KM, Guo X, Qin L. Microcomputed tomography detects trabecular architecture in adolescent idiopathic scoliosis - comparison with bone mineral status. 22nd Annual Congress, The Hong Kong Orthopaedic Association, Nov 2002, p. S90.

23. Cheng JC, Tang SP, Yeung HY, Lee KM, Guo X, Qin L. Evaluation of apoptosis in bone and cartilage of osteopenic adolescent idiopathic scoliosis by electron microscopy and TUNEL assay. 22nd Annual Congress, The Hong Kong Orthopaedic Association, Nov 2002, p. S89.
Szivek, John A. Monitoring Spinal Fusion in Scoliosis Patients: A Biomechanical & In Vivo Study $54,000 1998
  Publications:

In Vivo Strain Measurements from Hardware and Lamina during Spine Fusion, John A. Szivek, Rolando F. Roberto, in Review JBMR, 2004.

An Implantable Strain Measurement System Designed to Detect Spine Fusion: Preliminary Results from a Biomechanical and In Vivo Study, J. A. Szivek, R. Roberto, J. M. Slack, B. S. M. Majeed, SPINE, 27-5, 487-497, 2002.

Extended Abstracts in Transactions of Presentations:

In Vivo Strain Measurements from a Scoliosis Patient's Spine During the Initial Stages of Fusion J.A. Szivek, R. Roberto, J. M. Slack, B. S. M. Majeed, Trans. of Orthopaedic Research Society, New Orleans, LA, February 2003

Development of a Measurement Technique for In Vivo Monitoring of Spinal Fusion in Scoliosis Patients, A.C. Price, J.A. Szivek, R.F. Roberto, J. Invest. Med. Vol 48, No. 1, 61A, 2000.

Grants:
SRS results were used as supporting material in the following grant

2002 to 06
NIH-NIBIB:
National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering

PI
Sensate Scaffolds for Orthopaedic Tissue Repair
RSUM Supplement 2003-04
RSUM Supplement 2004-05
RSUM Supplement 2005-06
Engsburg, Jack Comparisons of Outcome Measures in Adult Scoliosis Patients Undergoing an Extended Spinal Fusion to L5 or Sacrum or Revision or Previous Long spinal Deformity Fusion $80,308 1998
  Publications:

Engsberg, J.R., K.H. Bridwell, A.K. Reitenbach, M.L. Uhrich, L.G. Lenke. 2001 APreoperative Gait Comparisons between Adults Undergoing Long Spinal Deformity Fusion Surgery (Thoracic to L4, L5, or Sacrum) and those with Able Bodies.@ Spine. 26(18):p.2020-2028.

Engsberg, J.R., K.H. Bridwell, J.M. Wagner, M..L. Uhrich, L.G. Lenke. 2003 "Gait Changes as the Result of Deformity Reconstruction Surgery in a Group of Adult Lumbar Scoliotics." Spine. 28(16):p.1836-1844.

Presentations:

Bridwell, K.H., J.M. Wagner, M.L. Uhrich, L.G. Lenke, J.R. Engsberg. September, 2001. Gait Changes as the Result of Deformity Reconstruction Surgery in Adult Female Lumbar Scoliosis. Presented at the Scoliosis Research Society Annual Meeting. Cleveland, Ohio.

Engsberg, J.R., K.H. Bridwell, J.M. Wagner, M.L. Uhrich, L.G. Lenke. 2002. Gait Changes following Deformity Reconstruction Surgery in Adult Lumbar Scoliotics. Presented at the Gait and Clinical Movement Analysis Society annual meeting. Chattanooga, TN.
Wise, Carol Identification of a Gene Involved in Hereditary Idiopathic Scoliosis $33,700 1997
  Publications:

"Localization of Susceptibility to Familial Idiopathic Scoliosis", C. A. Wise, R. Barnes, J. Gillum, J. A. Herring, A. M. Bowcock, M. Lovett, SPINE 2000, 25, (18), 2372-2380.

"Identification of a Gene Involved in Idiopathic Scoliosis", C.A. Wise, D.L. Caudle, R. Barnes, J.A. Herring, H. Hobbs, M. Lovett, A.M. Bowcock, J Bone Joint Surg (Br) 1998, 80-B, 219-220.

Published Abstracts:

Wise CA, Herring, JA, Weirich, K, Edwards, L, Lovett, M, Bowcock, AM. Identification and analysis of candidate genes for familial idiopathic scoliosis. Scoliosis Research Society (SRS) annual meeting, Sept. 2002, Seattle, WA (podium presentation).

Wise CA, Herring JA, Gillum JD, Zhang, D, Lovett, M, Bowcock AM. Positional cloning of candidate genes for familial idiopathic scoliosis. Scoliosis Research Society annual meeting, Sept. 2001, Cleveland, OH (podium presentation).

Wise, CA, Herring JA, Shoemaker S., Gillum JD, Gunn HC, Lovett M, Bennett LB, Bowcock AM. Evidence of susceptibility loci in genome wide searches of familial idiopathic scoliosis. American Society of Human Genetics annual meeting, Oct 2000, Philadelphia PA (poster presentation).

Wise CA, Herring JA, Gillum JD, Gunn HC, Lovett M, Bowcock AM. Evidence of susceptibility loci in genome wide searches of familial idiopathic scoliosis. Scoliosis Research Society annual meeting, Oct. 2000, Cairnes, AU (podium presentation).

Wise CA, Barnes R, Herring JA, Gillum JD, Macleod L, Hobbs HH, Bowcock AM, Lovett M. Genome-wide linkage scan for familial idiopathic scoliosis. American Society of Human Genetics annual meeting, Oct. 1999, San Francisco, CA.

Wise CA, Barnes R, Herring JA, Bowcock A, Lovett M. Localization of susceptibility to familial idiopathic scoliosis. Scoliosis Research Society annual meeting, Sept. 1999, San Diego, CA.

Presentations:

Wise CA. Localization and analysis of candidate genes for idiopathic scoliosis. Presentation to Cotrel Foundation, Paris, France, November 2003.
Lowe, Thomas Multicenter Longitudinal Study of Platelet Calmodulin Levels in AIS $29,926 1997
  Presentations:
"Platelet Calmodulin Levels in Adolescent Idiopathic Scoliosis (AIS): A Predictor of Curve Progression in AIS", [paper] North American Spine Society 15th Annual Meeting, New Orleans, Louisiana October 2000.

"Platelet Calmodulin Levels in Adolescent Idio pathic Scoliosis (AIS): A Predictor of Curve Progression and Severity", [paper] Scoliosis Research Society - 35th Annual Meeting, Cairns, Queensland, Australia, October 2000.

Papers:
Lowe TG, Lawellin D, Smith D, O'Brien MF, Price C, Haher T, Merola A: Platelet Calmodulin Levels in Adolescent Idiopathic Scoliosis (AIS): A Predictor of Curve Progression and Severity? Spine 27(7):768-775, 2002.

Lowe TG, Burwell RG, Dangerfield PH: Platelet calmodulin levels in adolescent idiopathic scoliosis (AIS): can they predict curve progression and severity? Summary of an electronic focus group debate of the IBSE. Eur Spine J. 2004 May;13(3):257-65. Epub 2004 Jan 09.
Stokes, Ian Rationalized Patient Specific Design for Surgery for Spinal Deformity $42,000 1996
  Publications:

1. AUBIN C+, Goussev V, Petit Y. Biomechanical Modeling of Segmental Instrumentation for Surgical correction of 3D Spinal Deformities Using Euler-Bernoulli Thin-Beam Elastic Deformation Equations, Medical & Biological Engineering & Computing. 2004; 42:216-21.

2. Petit Y, AUBIN C+, Labelle H. Spinal shape changes resulting from scoliotic spine instrumentation expressed as intervertebral rotations and centres of rotation. Journal of Biomechanics. 2004; 37(2): 173-180.

3. Petit Y, AUBIN C+, Labelle H. Patient-Specific Mechanical Properties of a Flexible Multi-Body Model of the Scoliotic Spine. Medical & Biological Engineering & Computing. 2004; 42(1):55-60.

4. AUBIN C+, Petit Y, Stokes IAF, Poulin F, Gardner-Morse M, Labelle H. Biomechanical modeling of posterior instrumentation of the scoliotic spine. Computer Methods in Biomechanics and Biomedical Engineering 6[1], 27-32. 2003.

5. Delorme S, Violas P, Dansereau J, De Guise J, AUBIN CE, Labelle H. Preoperative and Early Postoperative Three-Dimensional Changes of the Rib Cage After Posterior Instrumentation in Adolescent Idiopathic Scoliosis. European Spine Journal 10[2], 101-106. 2001.

6. Delorme S, Labelle H, AUBIN C+, De Guise JA, Rivard CH, Poitras B et al. A Three-Dimensional Radiographic Comparison of Cotrel-Dubousset and Colorado Instrumentations for the Correction of Idiopathic Scoliosis. Spine 25[2], 205-210. 2000.

7. Delorme S, Labelle H, AUBIN C+, De Guise JA, Rivard CH, Poitras B et al. Intra-operative Comparison of Two Instrumentation Techniques for the Correction of Adolescent Idiopathic Scoliosis - Rod Rotation and Translation. Spine 25[6], 77S-83S. 2000.

8. Delorme S, Labelle H, AUBIN C+, De Guise JA, Rivard CH, Poitras B et al. Intraoperative Comparison of Two Instrumentation Techniques for the Correction of Adolescent Idiopathic Scoliosis - Rod Rotation and Translation. Spine 24[19], 2011-2017. 1999.

9. Poulin F, AUBIN C+, Stokes IAF, Gardner-Morse M, Dansereau J, Labelle H. ModTlisation biomTcanique de lÆinstrumentation du rachis scoliotique a lÆaide de mTcanismes flexibles. Annales de Chirurgie 1998; 52: pp. 761-767.

10. Verniest F, Chopin D, Godillon-Maquinghen AP, Drazetic P, AUBIN C+, Lepoutre FX. Spinal surgery procedure discretization. Research into Spinal Deformities 3. IOS Press. 88, 438-441. 2002.

11. Verniest F, Petit Y, Chopin D, Godillon-Maquinghen AP, Cheriet F, Drazetic P, AUBIN C+. Biomechanical simulation of Colorado instrumentation of the scoliotic spine: a preliminary study. Research into Spinal Deformities 3. IOS Press. 88, 415-418. 2002.

12. Stokes IAF, Gardner-Morse M, AUBIN C+, Poulin F, Labelle H. Biomechanical simulations for planning of scoliosis surgery. Stokes IAF, editor. Research into Spinal Deformities II 59, 343-346. 1999. IOS Press.

13. Stokes IA, Gardner-Morse M, AUBIN C+, Poulin F, Labelle H. Biomechanical simulations for planning of scoliosis surgery. Research into Spinal Deformities II 1998; 59 :343-346.

Grants:
Aubin C. et al.
Development of a User-Oriented Spine Surgery Simulator (S3) for the Planning of Advance Instrumentation Design

CRSNG
R&D coop

165 000$/yr 2004-2005

Aubin C.
ModTlisation par TlTments finis et prototypage virtuel dÆorthFses et dÆinstrumentations pour la correction des dTformations musculosquelettiques de la colonne vertTbrale

Conseil de recherche en sciences naturelles et genie du Canada (CRSNG)

30 000$/yr 04/2001 - 03/2005

Aubin C.
Chaire de recherche du Canada ½ Innovations CAO en gTnie orthopTdique + Conseil de recherches en sciences naturelles et gTnie du Canada (CRSNG)

Chaire de recherche du Canada

$500,000 01/2001 - 12/2005

Aubin C, Dansereau J, Labelle H et coll.
Development of a simulator for virtual prototyping of spinal deformity surgeries

CRSNG

R&D coop UniversitT /Industrie
$443,900 12/2000 - 11/2003

Labelle H, Dansereau J, Aubin C, de Guise JA
Chirurgie assistTe par ordinateur pour le traitement des scoliosis idiopathiques

Conseil de recherches mTdicales du Canada (CRM)

$278,661 09/1999 - 8/2002

Aubin C, Dansereau J, Labelle H, de Guise JA, Allard P, Stokes IAF
AmTnagement dÆun laboratoire de modTlisation biomTcanique et de chirurgie du rachis assistTe par ordinateur

Fondation Canadienne pour lÆInnovation (FCI)

$483,000 04/1998 - 03/2002

Beauchamp G, Aubin C+, Yahia LH, et al.
Consortium sur lÆinnovation technologique en chirurgie

Valorisation Recherche QuTbec (VRQ)

$200,000 01/2000 - 01/2001

Aubin C+
ModTlisation biomTcanique par TlTments finis des man£uvres dÆinstrumentation du rachis scoliotique

Fonds pour la formation de chercheurs et lÆaide a la recherche (FCAR)

$43,800 06/1998 - 05/2000
Miller, Nancy Hadley Genetic Linkage Analysis and Fine Mapping of Familial Idiopathic Scoliosis $34,957 1995
  Presentations/Posters:
Characterization of Idiopathic Scoliosis in a Defined Population
SRS, 1999

Stratification for Complex Disorders with Genetic Heterogeneity Comprising Both X-linked and Autosomal Dominant Forms of Inheritance: Families with Familial Idiopathic Scoliosis
American Society of Human Genetics, 2000

Familial Idiopathic Scoliosis: Evidence of an X-liked Susceptibility Locus
SRS, 2001

Genetic Heterogeneity Comprising Both X-linked and Autosomal Dominant Forms of Inheritance: Families with Familial Idiopathic Scoliosis
American Society of Human Genetics, 2001

Familial Idiopathic Scoliosis: Evidence of an X-linked Susceptibility Locus
Orthopaedic Research Society, 2002

Familial Idiopathic Scoliosis: Evidence of an X-linked Susceptibility Locus
American Academy of Orthopaedic Surgeons, 2002

Identification of Genetic Loci Involved in Familial Idiopathic Scoliosis
American Society of Human Genetics, 2002

Publications:
Stratification for Complex Disorders with Genetic Heterogeneity Comprising Both X-linked and Autosomal Dominant Forms of Inheritance: Families with Familial Idiopathic Scoliosis. Justice, CM, Miller, NH, Marosy, B, Pugh, EW, Wilson, AF. Am J of Hum Genet 67 sup.2, No. 4, 2000.

Genetic heterogeneity comprising both X-linked and autosomal dominant forms of inheritance in families with familial idiopathic scoliosis. Justice CM, Miller NH, Marosy B, Zhang J, Pugh EW, Wilson AF. Am J Hum Genet 69 (Suppl): 384., 2001.

Characterization of Idiopathic Scoliosis in a Clinically Well-defined Population. Miller, NH, Schwab, D, Sponseller, PD, Manolio, T, Pugh, E., Wilson, A. Clin. Orthop. 392:349-357, 2001.

Familial Idiopathic Scoliosis: Evidence for an X-Linked Susceptibility Locus. Justice, CM, Miller, NH, Marosy, B, Zhang, J, Wilson, AF. Accepted for publication, Spine, 2002.
Spivak, Jeffrey Bioactive Cement of Augmentation of Transpedicular Screw of Fixation $49,975 1994
  Publications:
Spivak JM, Neuwirth MG, Labiak JJ, Kummer FJ, Ricci JL: Hydroxyapatite-enhancement of posterior spinal instrumentation fixation. Spine 19:955-964, 1994.