Scoliosis Research Society
SRS: Scoliosis Research Society

Scoliosis Research Society

Dedicated to the optimal care of patients with spinal deformity

NEWS RELEASE: SRS Collaborates to Complete ASLS II Study

March 1, 2018

Contact: Ashtin Neuschaefer, Scoliosis Research Society
Phone: 414-289-9107

Scoliosis Research Society Collaborates with Corporate Partners
International Spine Study Group to Complete ASLS II Study

Milwaukee, WI (February 1, 2018) – The Scoliosis Research Society (SRS) has partnered with Globus Medical; K2M, Inc.; Medtronic; NuVasive; Zimmer Biomet; and the International Spine Study Group Foundation (ISSGF) to provide continued funding and research infrastructure for the Adult Symptomatic Lumbar Scoliosis (ASLS) II study.

The ASLS II is continuation of the ASLS I study which was a prospective, randomized NIH funded study that evaluated the 2 year treatment outcomes of operative and non-operative treatment for adult patients aged 40 to 80 with symptomatic lumbar scoliosis. ASLS I began patient enrollment in 2009 and consisted of both prospective randomized and observational arms (observational participation for patents not consenting to treatment randomization). ASLS II will allow for longer term (8 year) follow up of the 258 patients remaining from the ASLS I study.

The study aims for ASLS II include evaluation of long term treatment outcomes and cost-effectiveness analysis of operative vs. non-operative treatment. Other study goals include optimal patient profiling for treatment efficacy, long term functional assessment of patients using functional treadmill testing, and assessment of treatment durability for operative and non-operative treatment.

Patients will complete basic follow-up every six months; full data sets (patient reported outcomes [PROs], medical assessment, radiographs) at years 4, 5 and 8; with interim PROs in years 6 and 7. Full data sets will also be collected prior to and approximately 3 months after any crossover or revision surgery. The 8-year assessment will also include a repeat functional treadmill test (FTT). Study is currently underway at ten centers from around the United States and Canada. The ISSGF will act as the clinical research organization for the ASLS II study, and will serve to provide a research platform for the ASLS II study investigators for research organization, funding acquisition and distribution, as well as study updates and data analysis.  The study is scheduled to conclude in 2023.

The Scoliosis Research Society is a non-profit, professional organization, made up of physicians and allied health personnel. Our primary focus is on providing continuing medical education for health care professionals and on funding/supporting research in spinal deformities. Founded in 1966, SRS has gained recognition as the world's premier spine deformity society. Please visit for further information.


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